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These results show that Bcd activates transcription of its target genes in a manner (i.e., following an input-output relationship) that transcends its morphogenetic role in instructing A-P patterning (Figure 2B).
Our study provides an integrated, multiscale view of the relationship between Bcd and its target gene transcription, suggesting that this chemical reaction-driven relationship transcends its role in instructing A-P patterning.
However, such an idea is not easily accepted, because various cytokines, but not TCR-signals, play dominant role in instructing helper T cell differentiation.
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Since such on/off expression boundaries, which are common in developmental systems, play critical roles in instructing cell fates, understanding the precise mechanisms leading to these outcomes represents a fundamental problem in biology [14], [15], [16].
In summary, tenm3 is expressed by RGCs, amacrine cells, and tectal neurons, consistent with a possible role of tenm3 in instructing connectivity along the visual pathway.
Our secondary data analyses have illustrated the important role of nurses in instructing and empowering non-smoking women, in a paediatric hospital setting, who might not otherwise have taken any action to help their husbands quit smoking.
The present work deals with the trafficking of glycosphingolipid GD3 to the mitochondrion upon pro-apoptotic triggering induced by CD95/Fas ligation and identifies the pivotal role of microtubule-associated protein CLIPR-59 in instructing and regulating GD3-microtubule association.
Nevertheless, only a transient Notch signal is required in CLP cultures, consistent with a role for this pathway in suppressing alternative cell fates, rather than in instructing ILC2 differentiation per se [ 10 ].
While a comprehensive approach with community, schools, and policies might be more effective, this study indicates that the ED may have a role in introducing and instructing patients about these lifestyle changes.
The therapist plays a key role in teaching and instructing these principles.
In this application, Occupational Safety and Health Council in Hong Kong played an important role to instruct the design and execution of SC principle and suggest ways to crystallize a culture of safety within a Chinese community.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com