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Additional support for the major role gap junctions play in neurogenesis (this time in adult), comes from work done in hippocampus (Kunze et al. 2009), where mice lacking Cx30 and Cx43 in radial glia-like cells (that would otherwise allow tracer diffusion between cells) display almost complete inhibition of proliferation and a reduced number of granule neurons.
Inhibitors of gap junction function showed a role for gap junctions in transmigration of eosinophils and neutrophils through endothelial monolayers.
Reduced conduction velocity during AF can be induced by reduced gap junction conductance; however, the role of gap junctions on the occurrence of AF is controversial.
The reviewers suggest testing the role of gap junctions by modulating cone-cone gap junctions with D1 agonist or antagonists.
Such a role of gap junctions in the spread of injury is observed in the brain following hypoxia-ischemia [ 167].
Our study highlights the role of gap quality for breeding birds; therefore improving the quality of gap habitats especially maintaining dead wood should be considered as an important conservation factor.
However, the role of gap junctions in memory formation can be interpreted as follows: Gap junctions could register already generated cyclic pathways in the syncytium (formalized as a sequence of negation operators).
To investigate the role of gap junction in the occurrence of AF, the effects of a gap junction enhancer (rotigaptide) and a blocker (carbenoxolone) on AF vulnerability, ERP and conduction velocity were analysed in the isolated rabbit heart.
Thus, alterations in the expression of GAP-43 are found in different disease conditions, inviting discussion of the role of GAP-43.
The role of gap junctions was firmly established when pharmacological agents were used to block gap-junction function in wild-type embryos, and this reproduced the L-R patterning defects seen in the Sox17-null embryos.
The aim of this study was to investigate the role of gap junctions in atrial fibrillation (AF) by analysing the effects of a gap junction enhancer and blocker on AF vulnerability and electrophysiological properties of isolated hearts.
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