The 44-year-old actor, formerly a rom-com regular whose roles centred on his good looks, lost 50lbs (23kg) to play Woodroof in the low-budget indie drama.
It is unclear whether CEP-1 is functionally more related to mammalian p53 or to either of the two other mammalian p53 family members p63 and p73 that are implicated in DNA damage responses but also fulfil multiple developmental roles centred on epithelial development and neurogenesis respectively [ 9].
The dimension of formalisation, which encapsulates the structuring of clinical care, was highlighted in the way the pharmacist's role was centred on medicines management, allowing staff to share roles and patient care.
Older women's social role in Nepal is restricted to household life, whereas the male role is more broadly centred on social networks.
Grant's role in the uprising centred on his house at Norbrook, ideally located in the English Midlands close to Warwick and Stratford, and to Catesby's childhood home at Lapworth (then owned by John Wright).
The dispute has centred on the role of conductors on new trains.
Most speculation, to date, has centred on the role of his ex-wife, who does seem quite keen to see his political goose cooked.
Berthollet initially favoured the phlogiston theory promoted by the German chemist Georg Ernst Stahl, but his experiments in pneumatic chemistry persuaded him to abandon it in favour of Lavoisier's explanations, which centred on the role of oxygen.
But now, though buying Dow would set a new record for private equity, it would not be by much.Inevitably, the firings have provoked an orgy of speculation, much of it centred on the role of the firm's bankers.
It should be considered alongside St. Gregory I's Pastoral Care (6th century): though centred on the role of bishops, rather than secular lords, Gregory's emphasis on humility as a key virtue of those holding worldly power, on the moral temptations of secular might, and on the need to provide moral leadership by example made it a key reference point for future writers.
Operation Young centred on the role of Dutch national governance in relation to youth and family policy.
