Their physiologic role in inflammation and pathologic role in HF are being increasingly recognized [ 47].
Members of the BMP and Wnt protein families play a relevant role in physiologic and pathologic bone turnover.
VEGF, a 35- to 45-kDa dimeric polypeptide, plays a critical role in normal and pathologic angiogenesis [3].
RAF kinases are serine/threonine kinases whose activity is modulated by growth factors and that play a central role in normal and pathologic cellular processes, including development, cell regeneration, cell senescence and cancer [16].
Angiogenic factors have an essential role in normal and pathologic angiogenesis.
Such a broad range of biological activities suggests a fundamental role in normal and pathologic developmental processes and stimulates questions regarding the contribution of 14q32-encoded mins in the evolution of oligo- and poly-metastases.
The VEGF pathway plays a crucial role in normal and pathologic angiogenesis, triggering multiple signaling networks that result in endothelial cell survival, migration, proliferation, differentiation, and vascular permeability [ 25].
In human medicine there is a body of evidence that β2 receptors are not only represented into the tracheal and bronchial musculature, but also in the atrium and ventricular myocardium and play a significant role in physiologic and pathologic conditions [ 14],[ 15].
DNA methylation is an important epigenetic event playing crucial roles in physiologic and pathologic processes.
These protease inhibitors have major roles in physiologic and pathologic processes such as angiogenesis, intravascular fibrinolysis, wound healing, and tumour invasion and metastasis (Janciauskiene, 2001; Brantly, 2002).
