The serotonergic system plays an important role and alterations in serotonin metabolism and in the processing of central serotonin-mediated responses are typical features among migraineurs [20].
The neurotransmitter serotonin appears to play a pivotal role and alterations in serotonin metabolism and in the processing of central serotonin-mediated responses have been described as typical for migraineurs [2].
Mitochondrial permeability transition pore (mPTP) plays a central role in alterations of mitochondrial structure and function leading to neuronal injury relevant to aging and neurodegenerative diseases including Alzheimer's disease (AD).
This manuscript revisits osseointegration addressing the individual and combined role of alterations on the macrometer, micrometer, and nanometer length scales on the basis of cell culture, preclinical in vivo studies, and clinical evidence.
Recently, there has been growing interest about the potential role of alterations of KGF/KGFR signaling in epithelial tumorigenesis.
Malaria could achieve this role through alterations of the placental cytokine environment in HIV-1 positive women [34].
Our study reveals a potential role for alterations in autophagy and neuritic morphology in mediating the pathogenic effects of LRRK2 mutations in vivo.
These changes in enteric neurons are likely to play a role in alterations in motility and secretory functions of the gastrointestinal tract [5].
While several mechanisms have been implicated in mediating this T cell specific downregulation, a role for alterations in the homeostasis of T effector and memory cell populations has not been explored.
In this scope, the myofiber itself constitutes one of the main niche components and our model in which it is the only mutated component strongly supports a major role for alterations coming from the myofibers in the age-related process.
