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It transforms rodent fibroblasts and induces expression of angiogenic factors [ 35].
Similar oncogenic properties were displayed in rodent fibroblasts and transgenic mice [ 15].
BARF1 displays oncogenic activity when expressed in rodent fibroblasts and simian primary epithelial cells [65].
In contrast to SV40 sT and MCV LT, MCV sT exhibits oncogenic activity: it transforms rodent fibroblasts and promotes serum-independent growth of human fibroblasts.
BamHI-A reading frame-1 may play an important role in nasopharyngeal oncogenesis, because it transforms rodent fibroblasts and primary epithelial cells and enhances tumor formation.
Rodent fibroblasts and human mammary epithelial cell lines transformed by the H-Ras oncogene do not express tyrosine phosphorylated Stat3 [ 17- 19].
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SSc AFA-positive sera bound to all human and rodent fibroblasts tested but not to human primary endothelial or smooth muscle cells.
Others have found that Stk can transform immortalized rodent fibroblasts [ 23, 24], and we hypothesized that if Hyal2 does downregulate RON/Stk activity, we might be able to suppress transformation by RON/Stk by overexpressing Hyal2.
On the other hand, SRSF1 can act as an oncogene since a twofold increase in expression can transform immortalized rodent fibroblasts [ 73, 79] and human mammary epithelial cells [ 73, 79].
Exposure to low levels of ROS can stimulate the growth of many types of mammalian cells, whereas scavengers of ROS suppress normal cell proliferation in human and rodent fibroblasts.
In contrast to tumour cells, for normal human and rodent fibroblasts, the variation in cellular sensitivity did not result from differences in the induction, but the repair of dsb (Dahm-Daphi et al, 1994; Kiltie et al, 1997; Zhou et al, 1997a, 1997b; Dikomey et al, 1998, 2000).
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