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To study the molecular mechanism underlying UC, a rodent colitis model induced by dextran sodium sulfate (DSS) has been commonly used.
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We suggest that H. muridarum may act as a confounding factor in colitis model studies in rodents.
The most widely used colitis model is the DSS model where rodents are given 2 5% DSS in the drinking water.
(C) Colon length of the colitis model mice and control groups.
This study was designed to investigate the effects of parthenolide on an experimental murine colitis model.
A standardized murine TNBS colitis model was used to induce acute levels of inflammation [49].
Based on its anti-inflammatory properties and previous success in colitis studies, we investigated the effects of IFN-β in a murine colitis model.
DSS colitis model were established as described elsewhere [ 16].
However, the colitis model using DSS with or without carcinogen needs to a long period and repeated administration of DSS to induce colitis and colitis-related CRC.
- Ting et al. showed that NLRP3 signaling modulated colitis and colitis-associated cancer in a dextran sulfate induced colitis model in mice.
Moreover, 11β-HSD1 inducedced in cells recruited into the peritoneum during sterile peritonitis (9) and is increased in intestine in both human and rodent colitis (14, 15).
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