Your English writing platform
Discover LudwigExact(2)
The highly compact nature of the rod nucleus may have favoured the detection of the fibers and special care was taken to perturb as little as possible the nuclear organisation during specimen preparation.
This layer of the rod nucleus is highly heterogeneous and contains intermingled Eu- and Heterochromatin but it is tempting to speculate that transcriptionally inactive genes are located in this compact but acetylated HC territory whereas actively transcribed genes are placed in the adjacent EC territory.
Similar(58)
The number of particles per µm2 was quantified for 15 20 rod nuclei for each immunolabelling experiment.
In rod nuclei the accumulation of H3K27me3 around the central core is consistent with a developmentally regulated onset of these marks [34].
After post staining with uranyl acetate and lead citrate, 100 nm thick retina sections observed by transmission electron microscopy revealed the characteristic appearance of rod nuclei which show a large electron dense HC domain located in their center (Figure 1B).
Bathyergids feature small lenses that collect light rather ineffectively (e.g., [8]), high cone proportions [11] and rod nuclei with conventional architecture (Němec et al., unpublished data; cf., [16]).
The number of rod nuclei was reduced by about 30 to 40% in Rpe65−/− retinas, which is in accordance with previous observations [4], [10], [29], whereas ONL thickness was preserved in double knock-out retinas as compared with wt retinas.
Our results show that the characteristic central heterochromatin of rod nuclei is organized into concentric domains characterized by a progressive loosening of the chromatin architecture from inside towards outside and by specific combinations of silencing histone marks.
As shown in previous studies, we confirmed following morphological examination (Figure 3A) and counting of rod nuclei (Figure 3B) that no change in outer nuclear layer (ONL) thickness, containing the photoreceptor nuclei, was obvious in Bax-deficient retinas as compared to wt retinas.
Low expression of MECP2 in rod photoreceptors was found in both the inverted rod nuclei of nocturnal mammals and the conventional rod nuclei of diurnal mammals.
In mice of both genotypes, rod nuclei had the same morphology as the rod nuclei in the wild-type littermate controls [ 38].
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com