Sentence examples for rock isoforms from inspiring English sources

To date, two ROCK isoforms have been described, namely ROCK-1 and ROCK-2.

Interestingly, we found that the two ROCK isoforms have opposing roles in regulating keratinocyte terminal differentiation.

Recently, functional differences between the two ROCK isoforms have become more apparent.

Here we have shown that the two ROCK isoforms have distinct roles in the regulation of keratinocyte adhesion to fibronectin (Figure 2A).

Our data suggest that both ROCK isoforms play distinct and important roles in regulating keratinocyte differentiation status and keratinocyte adhesion to the ECM protein fibronectin.

Our data confirm that both ROCK isoforms are expressed in cultured human keratinocytes and that each isoform can be specifically depleted, with no effect on the expression of the other (Figure 1A D).

Depletion of ROCK1 or ROCK2 had no effect on expression of the other, non-targeted, ROCK isoform (Figure 1A, C).

However, the relevant ROCK isoform (ROCK1 or ROCK2) in acute stroke is not known.

The protein level of ROCK isoform ROCK2 was found to be 2.5-fold higher in endothelium-intact aortic rings of the diabetic rats compared to those of the controls while its level in endothelium-denuded rings was similar among these two groups.

Our studies, with isoform-selective deletions of ROCK, dissociate ROCK-dependent peripheral (ROCK1 and ROCK2 dependent) and central stress fiber organization (mainly ROCK2 dependent).

The two Rho kinase isoforms (Rock 1 and 2) are highly conserved serine/threonine kinases with similar expression patterns and apparent roles during embryonic development.