Exact(18)
Every time I throw a rock, I am screaming, loud.
"I am a rock, I am an island..."...
Close to the rock, I saw no sign of art.
When my words were rock I was river.
For those about to rock, I salute you.
When I think of rock, I think of heavy metal.
Similar(42)
However, mutation of effector site residues (Val56, Phe57 and Tyr60) did not inhibit binding to ROCK-I1−420 ROCK-I1−420horphorylation of RhoE in cells, consistent with the lack of involvement of these effector residues in ROCK-I interactions.
This shorter ROCK-I fragment interacted with RhoE indistinguishably from ROCK-I1−420 ROCK-I1−420ary Figure Supplementary Figuretion of both ROCK-I proteinS1Anduced stress fibres in Swiss 3T3 cells (Supplementand Figure S1B).
PDK1 drives ROCK-I to the plasma membrane where it stimulates actomyosin phosphorylation and contraction, while Rnd3 can bind to ROCK-I and inhibit its activity, reducing motility.
Residues of RhoE that contact ROCK-I are poorly conserved in Rnd1 and Rnd2, explaining their inability to bind ROCK-I.
Interactions at the ROCK-I RhoE inteROCK-I RhoEominterface the α5 helix of RhoE are the αEF/αF loop andominatedx of ROCK-I.
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