Network-based design of MDTs can improve current drug regimes [ 11- 14] by identifying targets that both moderate the immediate characteristics of the disease while disarming its robustness strategies [ 7].
To overcome these limitations, we have proposed a multi-parametric robustness analysis strategy: by opportunely leveraging a global sensitivity analysis method, and combining it with the information provided by our DA's analysis technique, we were able to certify the persistence of bistability in the face of multiple variations of the uncertain parameters.
Our study shows that redundancy, typically perceived as a ubiquitous robustness-enhancing strategy in nature, can either improve or undermine robustness depending on the magnitude of the perturbations.
Rigorous MDO and robustness design strategies are critical to delivering high-quality products at low costs.
The effective implementation of multidisciplinary design optimization and robustness design strategies necessitates engineering process integration across a heterogeneous computing environment.
In the future, they also will need to pay attention to key issues such as risk management, trading algorithm reliability, platform robustness, trading strategies and record tracking, and market transparency.
Well-conducted public participation, stakeholder consultation and deliberation procedures can enhance the policy process and improve the robustness of strategies dealing with high-stakes investment and risk management challenges.
Forecast errors exert inevitable disturbance on the robustness of scheduling strategy.
With this strategy, robustness of the designed NES can be improved significantly.
Our study demonstrated the robustness of this strategy combined with cryo-EM in efficient and accurate subunit identification in challenging multi-component complexes.
