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These initiatives are of immense significance in establishing the robustness of trial strategies where patient recruitment is a challenge.
By removing unreasonable analyses that might have been performed, these questions will lead to relevant sensitivity analyses, which help to assess the robustness of trial results.
323 Finally, sensitivity analyses are highly recommended to assess the robustness of trial results under different methods of handling missing data.
The aims were to produce baseline data which would inform decisions for the main trial design (i.e. population, primary outcome, sample size calculation) and to optimize the robustness of trial processes within the study setting.
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We aimed to identify factors unrelated to the reported intervention that might have affected the findings and robustness of such trials.
These problems are representative of the limitations of collecting retrospective data in the real world compared to the robustness of clinical trials.
Taking advantage of this inter-individual heterogeneity to identify predictive markers of the clinical evolution could help to increase the robustness of preclinical trials on the one hand, and unveil mechanisms underlying variations in disease expression on the other hand.
As a check on our results (sensitivity analysis), we also ran the meta-analyses using MD in place of SMD, and assessed robustness of results to trial quality (trials assessed as at moderate or high risk of bias were removed).
Also, the size and robustness of the clinical trials made it a less attractive area for us to be in compared to other areas we were working in.
The novel means by which we have analysed the quality of this data has allowed the comparison of studies that lack the consistency and robustness of randomised controlled trials.
We sincerely hope that our responses reassure the readership of the validity and robustness of the telavancin clinical trial data.
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CEO of Professional Science Editing for Scientists @ prosciediting.com