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In this context it is interesting to note that one of the cis acting candidates at the chromosome 8 locus is Fto, a gene that has been robustly validated for association with human obesity [36] [38] and has recently been implicated in regulating energy expenditure in mice [39].
20 21 47 Nevertheless, their diagnostic performance has not been robustly validated in an independent cohort.
Taken together these results indicate that the gonad RNA-seq data was robustly validated by in situ hybridisation.
Of note, miRGate succeed to provide useful targets obtained from different transcriptomic techniques that were robustly validated.
A stratification of breast cancers into subgroups that enrich for drivers, the ideal therapeutic targets, has been recently robustly validated (Ali et al, 2014).
Our prediction model has been robustly validated across multiple centers, a larger sample size, and a wider geographic area, and uses variables that are potentially available soon after arrival in the emergency department.
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In addition, our method of combining existing data sets can be used to robustly validate the potential clinical value of any new gene expression profile.
The ISS is robustly derived and validated in large global cohorts and is easy to apply.
The score was robustly developed and validated in over 4,800 patients across diverse ethnic and socioeconomic groups.
A custom TaqMan gene expression assay to measure GFP mRNA was designed (Life Technologies) and its ability to robustly determine expression levels validated by standard curve.
Although existing data for baseline characteristics and CMML prognostication have been robustly developed and externally validated, these results have been limited by the small size of single-institution cohorts.
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CEO of Professional Science Editing for Scientists @ prosciediting.com