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Through this dual mechanism, PMVDS robustly stimulated both the humoral (> 32 times of IgG1 levels vs alum) and the cell-mediated immune responses against the encapsulated antigen (ovalbumin) in mice.
Addition of exogenous Hsp90α to serum starved G48a cells robustly stimulated phosphorylation of src, AKT and EphA2 (Figure 3A).
The hARD1/MLCK interaction was robustly stimulated by Ca2+ influx, which was abolished by Ca2+ chelation (Fig. 2A).
HPCs failed to stimulate allogenic T cells (Figure 1c), in contrast to splenocytes and bone marrow cells, which robustly stimulated T cells.
After src-phosphorylation cortactin could also be linked by Nck1 to N-WASP, and this complex (through the "VCA" domain of N-WASP) more robustly stimulated F-actin assembly by Arp2/3 than cortactin or N-WASP alone.
The results showed that FMNL2 robustly stimulated SRF activation, while FMNL2 silence markedly inhibited SRF activation (P < 0.01, Fig. 2e).
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During the cellular response to genotoxic stress PARP-1 rapidly associates with DNA damage, which robustly stimulates poly(ADP-ribose) production over a low basal level of PARP-1 activity.
We found that the APCs that express DLL1 or Jag1 could robustly stimulate luciferase activity in CHOfNotch2 cells.
As a coactivator of AR, FHL2 in turn robustly stimulates the AR activity that is critical for prostate cancer progression [48], [49].
Note that NGF application robustly stimulates CBFβ protein expression as indicated by increased Flag immunoreactivity.
When administered to humans in different isoforms, routes and doses, kisspeptin robustly stimulates LH secretion and LH pulse frequency.
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