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This sharply contrasts intact conventional gated ion channels that consist of tightly interacting α-helices that robustly prevent ion leakage, rather than hydrogen-bonded β-strands.
Because Plk1 is only partially destabilized after mitosis, this may provide a mechanism to robustly prevent re-activation of Plk1 in G1 and S phase.
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However, when an equimolar ratio of mtHsp70/J-protein (hTid-1S) was equilibrated to allow complex formation, followed by addition of rhodanese, wild-type mtHsp70 robustly prevented the aggregation of model substrate when compared with BSA control (Fig. 2C).
Our results revealed that neuronal lesion had no effect by itself in the FST, as previously shown (Banasr and Duman, 2008), but robustly prevented the antidepressant-like effect of IL-DBS.
"These procedures were not followed robustly enough to prevent some schools from falling into the category of 'school causing concern' when inspected by Estyn".
The control and DR food was prepared according to recommendations by Ja et al. [ 23] to prevent desiccation, which robustly resulted in prolonged lifespan of male and female w flies (Fig. S2).
Small molecule inhibition of CDC-7 by PHA767491 was further shown to robustly reduce TDP-43 phosphorylation and prevent TDP-43 dependent neurodegeneration both in vitro and in vivo [64].
A Mopac spokesperson said: "The Shield pilot is just one of many schemes to help tackle gang crime based on the mayor's commitment to prevent gang membership and help members leave gangs, robustly enforce the law against criminal behaviour and build support and confidence in local communities.
Advance preparation and bedside availability of oxytocin before childbirth was significantly and robustly associated with rapid administration of the utertonic, as recommended to prevent postpartum hemorrhage.
The offence we propose will not prevent people from debating or ridiculing religions and beliefs as robustly as happens today.
It is vital that the police and criminal justice system have a range of measures available to them to prevent drug use, [but] also have the tools to deal robustly with serious and repeat offenders who cause the most harm in our communities".
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CEO of Professional Science Editing for Scientists @ prosciediting.com