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The NPHS frailty index has been previously validated, and is robustly predictive of mortality [ 44].
The aim of these studies is typically to discover a set of genes that participate in a pathway and are robustly predictive of a biological phenotype in a meta-analysis of multiple studies.
For example, frailty increases with age as deficits accumulate at an average rate of three percent per year, women have higher frailty than men at all ages (but show better survival at any given level of frailty), and frailty is more robustly predictive of mortality than chronological age [ 44, 54].
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If this observation were to apply broadly to nonsynonymous SNPs, then robustly predictive calculations of the energetic effects caused by these mutations could, in principle, make a valuable contribution to genome sequence interpretation.
Examples of some of these robustly predictive gene sets are shown in Figures 3B-E as survival curves generated from the van de Vijver dataset.
This gene set was made up of genes that were shared across many robustly predictive gene sets.
The gene overlap network analysis yielded a novel gene set enriched in genes shared by the robustly predictive gene sets.
However, when training our models, we required only that the chosen genes/probes be robustly and reproducibly predictive of relapse.
The pattern of PBP expression robustly predicts the efficacy of dBH3s.
The three-lncRNA signature we discovered robustly predicts the survival of patients with OSCC.
The lack of health claims is probably attributable to the fact that, although numerous biologically plausible mechanisms have been established to explain inflammation disease associations, no single biomarker or cluster of biomarkers of inflammation has yet been robustly demonstrated to be sufficiently predictive of future disease.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com