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An association between PD and MAPT and the surrounding 17q21 locus results from an ancient paracentric inversion and was robustly implicated in clinical PD and in autopsy-confirmed series of PD in Caucasian populations [ 40- 42].
Given that the anterior insular has been robustly implicated in interoception (Craig 2009; Critchley et al., 2004), it is plausible that previous findings of insular activation on the UG might reflect the general representation of bodily responses (see also Kirk, Downar and Montague 2011), as opposed to activation of distinct negative affective states such as disgust or anger (Sanfey et al., 2003).
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The recurrent identification of POGZ in these studies has robustly implicated POGZ in diverse NDDs, yet no thorough clinical analysis for POGZ variant-associated phenotypic features has been published to date.
Genome-wide association study meta-analyses have robustly implicated three loci that affect susceptibility for smoking: CHRNA5\CHRNA3\CHRNB4, CHRNB3\CHRNA6 and EGLN2\CYP2A6.
Singing sturdily and steadily, Patricia Racette makes a touching Katerina, perhaps too gentle for someone so deeply implicated in violent crime, while Robert Hayward, Peter Hoare and John Daszak project robustly as the moronic men who drive her to destruction.
Furthermore, MAPK signals are robustly activated in a variety of disease states and have been implicated in mediating apoptotic responses.
In this context it is interesting to note that one of the cis acting candidates at the chromosome 8 locus is Fto, a gene that has been robustly validated for association with human obesity [36] [38] and has recently been implicated in regulating energy expenditure in mice [39].
Strikingly, the most robustly overrepresented motifs in our set match E- and D-boxes, the elements that have previously been implicated in the light response of the period2 gene [25].
Among GFINs robustly enriched for structural defects, the most enriched was that of the MXD family of genes that has been implicated in cancer pathogenesis58, thereby providing concrete genetic defects to explore the reported coincidence of specific cancers with the ASDs59.
He was not implicated in the inquiry.
It is implicated in the civilian deaths.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com