Genome-wide association studies have revealed that single-nucleotide polymorphisms in the first intron of the gene encoding fat mass and obesity-associated protein (FTO) are robustly associated with BMI and obesity.
Second, we demonstrated that 37 of these metabolites were robustly associated with variants at three different lipid-associated loci, including one metabolite associated with two loci, highlighting both known and potential new biochemical correlates (summarized in Table 3).
Variables which were robustly associated with cotinine (Table 3), showed similar associations in both sexes and did not vary by age in regression models with cotinine as a continuous or a dichotomous variable (all LR tests of interactions, P > 0.05).
Recent genome-wide association (GWA) studies have identified multiple loci robustly associated with BMI and risk of obesity.
However, the authors noted that although an inflammation score was robustly associated with onset of diabetes in whites, no association was found in the African American population.
We constructed genetic risk scores that summed each man's number of height and BMI increasing alleles across multiple single nucleotide polymorphisms robustly associated with each phenotype from published genome-wide association studies.
Genome-wide association studies have identified several variants that are robustly associated with obesity and body mass index (BMI), many of which are found within genes involved in appetite regulation.
Similarly, while low eGFR was robustly associated with all-cause mortality, only eGFRcys showed significant association with cardiovascular mortality.
The FTO signal was robustly associated with BMI and osteoarthritis, and showed evidence of association in the replication osteoarthritis dataset.
Genome-wide association (GWA) studies have identified a number of SNPs robustly associated with traits of dyslipidaemia in cross-sectional studies [9 16].
