Exact(2)
LPS evoked a robust systemic response that induced a stereotypical cytokine release.
(Table 3) Although patients with diabetes can present with systemic signs of infection (fever, nausea, vomiting, anorexia, malaise, loss of glycemic control, etc)., they may not mount a robust systemic response (12– 12).
Similar(58)
Both local mucosal immunity and robust systemic responses can be achieved through mucosal vaccination.
As Th17 responses have been associated with autoimmunity and CIA, we measured serial serum IL-17 levels after collagen immunization, with the hypothesis that mice with a more robust systemic Th17 response develop arthritis, while mice with a weaker Th17 response do not develop arthritis.
Moreover, mice mount a robust systemic immune response to Sendai virus and can rapidly clear the virus following a second infection, making the murine model less suitable for studies of anti-vector responses.
The presence of bacteria in the blood could theoretically potentiate a cytokine cascade resulting in a more robust systemic inflammatory response.
However, unlike many chronic infectious agents, Mtb actually promotes the development of a robust, systemic immune response, which it subverts at the localized tissue-level to facilitate its prolonged survival, and, ultimately facilitate its transmission (Russell, 2007).
Most strikingly, these mice were protected from salivary gland dysfunction and showed reduced infiltration in salivary and lacrimal glands, even though they still generated a robust systemic autoantibody response.
When applied to Drs-GFP flies, this infection procedure strongly activated the infection-responsive reporter in fat body tissue of the head, thorax and abdomen, indicating a robust systemic immune response.
Although primary infection usually occurs in childhood without marked symptoms, exposure during adolescence can elicit infectious mononucleosis, a condition characterized by significant flu-like symptoms, such as fatigue and malaise, but also lymphadenopathy and often splenomegaly, reflecting the robust systemic immune response to the virus.
Robust systemic IgG responses were induced by each immunization route (Fig. 1a).
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