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Specifically, we examine an important gene circuit, the bistable switch, and use the stochastic simulation algorithm to develop design principles that will enable us to produce a fast and robust switch for use in future applications.
A previous model of G1/S by Aguda et al., [33] found that although pRB and cyclin E-CDK2 formed a positive feedback loop, they did not form a sharp robust switch at the restriction point, i.e., the increase in active cyclin E-CDK2 concentration was gradual and sensitive to model parameters.
Coupling EcR positive auto-feedback to miRNA-mediated repression allows a robust switch function upon Ecdysone stimulation, while protecting the system from the effects of biological noise.
While the focus of the previous study was on the ON state, many biological systems require a robust switch that not only prevents spurious deactivation at the ON state, but also spurious activation at the OFF state.
Coupling EcR positive feedback to miRNA-mediated mutual repression allows a robust switch function upon Ecdysone stimulation, while protecting the system from the effects of random fluctuation in EcR levels that might otherwise trigger a feedback response.
In Experiment 1, we examined whether the switch cost would be eliminated by the requirement to shift attention with every update, and observed that a robust switch cost was still present.
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The designed robust switched controller has been successfully verified by experiments on a TITO laboratory plant.
In this work, we address the problem of robust switching design, which seeks a switching signal that makes the switched system exponentially stable and robust against switching perturbations.
In this paper, we consider the design of a robust switched PI controller for a simple hysteretic mechanical system.
The controller synthesis is generalized in a sense that it covers robust, robust gain-scheduled, and robust switched (with arbitrary switching algorithm) PID controller design.
This work deals with the design method of robust switched H∞PI observer-based control for switched uncertain systems with external disturbances.
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