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The robust substance traditionally made from burned bones should help protect the Solar Orbiter when it flies closer to the sun than any spacecraft before it.
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Eva Ibbotson, who has died peacefully at home aged 85, entranced her readers with stories which, though robust in substance, appeared to be effortlessly spun in the finest thread from an endless source of imagination.
The target was to design a sufficiently robust drug substance specification allowing to obtain a satisfactory drug product.
For the production of multigram quantities of this substance robust and scalable processes comprising several purification steps have to be designed.
This difference in alcohol-disorders could be a source of bias even though the overall contrast to the controls was robust, as any substance usage disorder was an exclusion criterion for controls.
In addition it was the most robust against inhibitory substances of all the chemistries tested and proved practical for routine use.
The debate offered viewers yearning for substance a robust discussion of municipal issues, in contrast with the previous face-off, which included questions on whether either candidate had ever had a professional manicure or pedicure.
A positive family history of SUD is a consistent and robust risk factor for substance use outcomes in first-degree relatives.
Based on this case study, we propose that a formulation can be claimed as "robust" if all drug substance and drug product critical quality attributes remain within their respective end-of-shelf-life critical quality attribute acceptance criteria throughout the entire claimed formulation composition range.
Methods: The first stage of the approach finds active substances with robust concentration response profiles within the tested concentration range.
The procedure effectively distinguishes substances with robust concentration response profiles (ACTIVE*[±1] and ACTIVE*[±2]) and compounds with nonrobust concentration response profiles (INCONCLUSIVE*[±3]).
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