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When D-dimer was modeled as a dichotomous variate, a robust significance was detected, but we only found a marginally significant positive association for it as a continuous variate.
In addition, the application of general linear mixed statistical models [ 18] coupled with the large effects of statins over time on some of the tested analytes permitted a number of conclusions of robust significance.
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The long follow-up period, the large and representative population based sample, adjustment for several possible confounders, robust significances, similar odds ratios for Alzheimer's disease and mild cognitive impairment, alternative calculations with consistent results, and similar odds ratios for non-participants all contribute to the credibility of our results.
RASSF1A and p16 both seem to be specific for SGTs and not normal parotid tissue although they did not meet robust statistical significance.
An implication of these observations is that it may not be wise to rely on single key genes as modulators of the observed effects, as the statistical reliability of any individual genes is moderate, compared to the robust statistical significance of coregulated or functionally-related gene groups.
It should be emphasized that any association made between a gene and its corresponding signature for any one dataset was quite robust, the significance values testing against 1000 randomly-generated gene signature and 1000 permutations of the reference oncogene values (see Methods).
The sigscape tool permits new, more robust statistical significance tests in cophylogenetic analyses.
For robust prognostic significance testing, other threshold values were also tested as indicated in results.
– The sigscape tool permits new, more robust statistical significance tests in cophylogenetic analyses.
Although we were unable to achieve robust statistical significance as seen in the BeadChip data, we did observe a slight decrease in DNA methylation in BPA-high samples.
Several studies have reported the ability of new biomarkers in both the earlier diagnosis of AKI and the robust prognostic significance [ 6, 7].
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