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Especially useful for dissecting complex signal transduction pathways are reporter constructs, that give a fast and robust readout of the signals running through the pathway of interest.
The mECT can be made using cells from existing mouse models of cardiac disease, providing a robust readout of contractile performance and allowing a rapid assessment of genotype phenotype correlations and responses to therapies.
The goal of the assay, however, was to design an assay in T-cells with a definitive and robust readout.
This assay provides a robust readout and might help conduct genetic and drug screening studies.
We found that an antibody combination of Pecam1 together with Cd47 or Cd40 provided the most robust readout.
First, we employed a robust readout of neurodegeneration the degeneration of the photoreceptor neurones (rhabdomeres) (Fig. 5A and B).
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Nuclear magnetic resonance spectroscopy (NMR) provides robust readouts of many metabolic parameters in one experiment.
The classifier is also robust to readout noise.
The advantages of 5/6 Nx model include robust functional readouts (such as proteinuria, GFR, and secondary hypertension), reliable induction in rodents, and comparison to the kidney removed at induction of injury.
Key to these results is the use of different pairs of 9Be+ hyperfine states for robust qubit storage, readout, and gates, and simultaneous trapping of 24Mg+ "re-cooling" ions along with the qubit ions.
Based on our findings we propose that microscopic analysis of the asymmetric distribution of VANGL2-EGFP is a robust and specific readout for the analysis of the PCP pathway.
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