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Green algae are some of the most robust organisms on earth, being able to inhabit a wide range of habitats (Tazaki et al., 1994; Lewis and Lewis, 2005).
Yet the robust organisms are able to accumulate genetic variation precisely because this variation is hidden from selection, i.e. because it is cryptic.
Thus, the prevalence of the robust organisms could possibly be biased upwards.
Robust organisms, such as S. aureus and Salmonella, are more likely to be isolated than fastidious ones [ 16].
In addition, upon invasion into a new habitat, robust organisms might be better able to accept new beneficial mutations, as the phenotypic changes upon new mutations would less likely lead to developmental/physiological catastrophe.
Molds grow on hams during the long curing and drying process because the high salt and low temperatures do not inhibit these robust organisms.
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Considering the ever-changing environment this robust organism faces in the host, with a regular onslaught of drugs and the need to constantly fine tune its metabolism according to the surrounding conditions, regulation effected by CTP may be an effective system to bring about rapid changes in the cellular CoA levels.
However, we frequently isolated S. pneumoniae, a less robust organism, which suggests that our aerobic culture techniques were adequate.
An overly robust organism might even become problematic unless we can control where the 'fragility' occurs and use this as a form of population control.
mobilis lacks the ability to ferment pentose sugars, and a major drawback is furthermore that it is not a very robust organism.
Furthermore, Physarum is a robust organism which can grow on many different substrates, making it a good candidate for development of synthetic biosensors [ 30].
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