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Because of their location and robust onset kinetics, we refer to these events hereafter as the "sub-PM [Ca2+]i upstroke (SPCU)".
Fate mapping, using the conditional reporter function of the PHOX2B∆8 mutant locus (Fig. 1c), showed robust onset of GFP expression in Phox2b+ cells at E10.5 with Hprt- cre, but only confined GFP+ population in Blbp- cre fate-mapped hindbrain.
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This figure demonstrates the value of convergence of a relatively large number of small AN inputs in producing a robust onset-type response.
Taken together, these experiments reveal robust early-onset protein expression changes correlating with synaptic and axonal pathology in the thalamus and cortex of Ppt1 −/− mice in vivo.
Similar to the case in Xenopus and Drosophila, cell cycle regulation in the presence of DNA damaging agents as well as resistance to killing by a DNA damaging agent become more robust after the onset of gastrulation in Hydractinia.
We focused on turbulence slope because previously this parameter was found to be more robust than turbulence onset in identifying participants with increased risk of cardiac events (Cygankiewicz et al. 2008).
Next, a stimulus position that evoked a robust and fast-onset response was selected and the average initial peak time after stimulus onset for the selected stimulus position was calculated.
Despite the low expression levels of mutant APP, Tg-SwDI mice develop early-onset robust accumulation of Aβ in the brain.
There was a strong temporal conservation of expression during the time of rapid axon development and the onset of robust synapse formation.
Warm, robust strings at the onset insinuated a sense of occasion.
High safety, robust efficacy, and rapid onset of action remain the key challenges for improving antidepressant drug discovery.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com