Despite extensive characterization, robust Mendelian inheritance, and full penetrance, both the physiological basis and the genetic basis for the cerebral pathology are yet to be determined.
Therefore, we argue that the number of CENP-A molecules found on human centromeres is optimized for robust epigenetic inheritance and centromeric function.
In summary, we present a quantitative view of the centromere that provides a mechanistic framework for both robust epigenetic inheritance of centromeres and the paucity of neocentromere formation.
In conclusion, our results demonstrate that Kingman's coalescent is robust to tetrasomic inheritance, making existing coalescent models applicable for analyzing population genomic data collected from natural autotetraploid populations that exhibit this mode of inheritance.
Traits are a more robust alternative to multiple inheritance and enable object composition and reuse.
An example of ordered inheritance is the robust segregation of chromosomes into daughter cells by microtubules of the mitotic spindle.
However we have found that modelling them as independent Gaussians with variance equal to the mean (as an approximation of the Poisson), makes the inference of the inheritance pattern more robust to noise.
While this approach proved a robust method for analysing cellular inheritance, the algorithms employed to predict the evolvution of the in-silico population are numerically bespoke requiring an in-depth knowledge of the biological principles and processes involved during the complex cell-cycle.
LDLA is also robust to non-additive modes of inheritance [ 4].
There are considerably more robust examples of the transgenerational epigenetic inheritance from model genetic organisms and wild plants, where it is easier to analyze aberrant epitypes and associated phenotypes through multiple generations.
However, the genetic inheritance of robustness might be lost after such long times, due to genetic drift or to competition with fitter, less robust, genotypes.
