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The objective of this study is to investigate a novel method for transdermal delivery using metal microneedle arrays (MN) coated with inactivated influenza virus to determine whether this route is a simpler and safer approach than the conventional immunization, capable to induce robust immune responses and confer protection against lethal virus challenge.
BCG induces robust immune responses in the bladder that are responsible for its antitumor effect.
In addition to creating robust immune responses, TLR ligands are also involved in the skewing of protective immunity upon vaccination.
Mice that had been primed with proteins from the dry-roasted nuts exhibited more robust immune responses to both diets.
We demonstrate the ability of this strategy to elicit robust immune responses.
Early clinical trial results show good tolerability and robust immune responses to both components.
Such robust immune responses caused by low dosage of adjuvant (CpG ODNs) could help to reduce the side effects in mice.
No data are yet available for trials in children, who typically have much less robust immune responses to the seasonal influenza vaccine and require a second dose.
In particular, Ballou says the ongoing trials should clarify which dose of the vaccine will trigger the most robust immune responses without side effects.
We demonstrate that robust immune responses are induced and that peptides containing the orthologous rodent Plasmodium sequences exhibited similar immunogenic capabilities.
However, immunization with DNA vaccines using conventional delivery methods often fails to induce consistent, robust immune responses, especially in species larger than the mouse.
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