Sentence examples for robust docking from inspiring English sources

Like Munc18 we observed that deficiency of syntaxin-1 also produced robust docking phenotypes in chromaffin cells (de Wit et al. 2006).

Previously we showed that deficiency of Munc18 (Voets et al. 2001) or the protein syntaxin-1 (de Wit et al. 2006) not only abolished exocytosis, but also produced robust docking phenotypes in chromaffin cells (Toonen et al. 2006a) as well as neurons (Toonen et al. 2006b).

In this paper, the issues of both optimal design and robust design of docking blocks with uncertainty are discussed, and the corresponding mathematical models are proposed.

The viability of these prediction algorithms, in particular the more robust in silico docking model, is perhaps best validated by the clinical success of tafamidis, the first-in-class drug approved in Europe, Japan, South America, and elsewhere for treating transthyretin aggregation-associated familial amyloid polyneuropathy.

Syntaxin deletion resulted in secretion defects and a robust reduction of docking in neurosecretory cells, but not in CNS synapses.

With the key modular elements established including a robust phosphorylation module and selective docking site module, the complete JNK1/2/3 sensor was developed after optimization of the linker between the two modules.

Although the signal in the cytoplasm is not as robust as the signal from the docked vesicles, the docking and fusion of ESMVs to cells is highly efficient as the vast majority of cells contain docked vesicles.

The system design is tailored to robust interaction through contact (e.g. docking and sliding on walls).

Calmodulin, due to interaction with Ca2+, undergoes a robust conformational change and exposes hidden hydrophobic docking site for trifluoperazine and other conventional calmodulin antagonists [18], [19], [46].

In this work, the focus has been set on the implementation and the validation of the fast and robust knowledge-based objective function PMF04 into the molecular docking program PARADDOCKS (Parallel Docking Suite) [1].

This paper illustrates a novel and robust optimization algorithm (CEPGA) for solving the protein ligand docking problems with an aim to overcome the above-mentioned drawback.