Sentence examples for robust checkpoint from inspiring English sources

However, subsequent work has shown that most CIN cancer cells have a robust checkpoint [8] and their response to mitosis perturbing treatments is undistinguishable from the response of non-CIN cells [8], [9].

This loss of robust checkpoint control and subsequent escape from G2 arrest is likely due at least in part to destabilization of mutant p53, combined with a cellular state in which there is insufficient p21 activity (both intrinsically and via the HSP90 inhibitor-mediated loss of mutant p53) to enforce the checkpoints.

When a DSB is present during DNA replication, it is very efficiently processed and induces a robust checkpoint response.

This may also explain the reported correlation between robust checkpoint response and drug sensitivity with platinum antitumour drugs (Vekris et al, 2004) and the reported abolishment of apoptosis in the presence of p21PCNA that cannot bind to PCNA (Chopin et al, 2004).

Similarly, in line with the original report implicating Tao1 in SAC function (Draviam et al. 2007), an override of the nocodazole-induced SAC arrest could be observed in response to siTao1-NCB3 (average duration of arrest 25 min), whereas a robust checkpoint arrest (often followed by cell death after 12 15 h) was seen upon depletion of Tao1 by siTao1-2 or siTao1-3 (Fig.  7c).

The most robust checkpoints feature crews of roughly 20 men, networks of trenches, bunkers and anti-tank barriers.

This is perhaps because normal cells, owing to robust checkpoints, have durable mechanisms that prevent cell-cycle progression in the presence of damaged DNA.

In our experience, modular workflows are executed in stages with optional human quality control; NSANE hence focuses on providing robust checkpointing and intuitive report generation (Fig. 1b).

In vertebrate, a two-step model has been proposed to explain the robust G1 checkpoint activation.

Indeed, studies have identified numerous phosphorylation events that are critical for a robust spindle checkpoint response (3).

COS7 cells have a robust spindle checkpoint and, in the presence of microtubule inhibitor, remain arrested in mitosis for at least 18 hours.