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By nature it is sensitive to robust changes in the energy content of the regional activation that are sufficiently high to stand out from the background level of activity.
Compared to a baseline condition in which participants heard their own voice as feedback, hearing a stranger's voice induced robust changes in the fundamental frequency (F0) of their production.
Our recent microarray analysis pointed to robust changes in the expression of glutamate transporters SLC1A1 and SLC1A3 upon resistance development in both HCT116 cells and LoVo cells (Additional file 1: Figure S1A) [ 13].
Furthermore, the Ob+Ab+ ASCs demonstrated more robust changes in the expression of both LEP (201.5-fold 201.5-foldand TRH (50.44-fold decrease; P <0.01; Addincreasefile 4; andiTRHnal file 50.44-fold 50.44-fold
Comparison of changes in gene expression from published microarray analysis of a distinct ts mutant, abf1 -101 (Loo et al. 1995), in a BY4741 background, revealed that this categorization is robust: changes in the two ts mutants strongly correlate and the two classes of targets are for the most part well demarcated.
DPAGT1 functions at a rate-limiting step in the N-glycosylation pathway, so modest changes in its expression result in robust changes in the N-glycosylation status of proteins (Clark et al. 1983; Hayes and Lucas 1983; Welply et al. 1985; Meissner et al. 1999; Mendelsohn et al. 2005; Bretthauer 2009).
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I don't disagree with that, but when you grow up in manufacturing or transportation, the incremental improvements you make every day are what create robust change in the end.
Our previous microarray study on smoke-exposed maize seedlings showed that smoke treatment results in a distinct, although not robust, change in the gene expression pattern.
Though concentrations above 4% were not investigated, it could be assumed from the statistical result that no robust change in the dissolution behaviour would be achieved.
The primary goal was to determine a possible anatomical substrate for the novel polysynaptic responses around the Hx in the triple combination treatment which gave the most robust change in the electrophysiological studies.
To find the genes with the most robust changes in expression, the data was plotted as a "Volcano Plot" (Supplementary Figure S2B), which allows statistical significance to be measured along with the extent of fold change in expression.
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