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When all TNPO3 candidate sequences were clustered by NJ, a cluster of robust candidates identified by phylogenetic analysis (data not shown), was formed with more diverged candidates being excluded (Figure S2(h)).
sscMap differs from these approaches by exploring the avenue of selecting robust candidates for the potential to alter the phenotype of disease using a modified framework of the original Connectivity Map.
A better means of identifying robust candidates early in the drug discovery process is clearly needed.
The novel robust candidates in the top 200 were Por, Azin1, and Gys2.
Our approach did not suggest any robust candidates for 4 earlier identified QTL.
Analysis of multiple transcriptomic datasets has the likelihood of discovering robust candidates for diagnosis and treatment.
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This creates a stable and robust candidate for low pH applications.
Full-inorganic halide perovskites, cesium lead halides, offered a robust candidate without sacrificing emission tunability or ease of synthesis.
Therefore, 3D nanocapacitor arrays with a high aspect ratio are considered to be a robust candidate to achieve a high capacitance density.
Unexpected selectivity issues versus tissue plasminogen activator in the former series were addressed in the later, delivering a robust candidate for progression towards clinical studies.
There are many obstacles along the journey from initial hit-finding activities, through optimization of compounds and eventually to delivery of robust candidate drugs (CDs) for clinical evaluation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com