A CME is defined as a robust barrier (mitigation element) that reduces the probability by one level on the company's risk matrix or, in some cases, reduces the consequence level.
Healthy, nourished, un-inflamed skin has a robust barrier function, and experiences less adult acne and other skin disorders.
Accelerated lifetime tests suggest robust barrier characteristics on timescales that approach 70 y, in layers that are sufficiently thin (less than 1 μm) to avoid significant compromises in mechanical flexibility or in electrical interface fidelity.
An even more robust barrier to tanks was provided by long lines of anti-tank cubes.
Furthermore, as we have shown previously, cen1 tDNAAla is transcribed and both intact TATA and A box regions are required for robust barrier activity [16].
Furthermore, recent in vivo studies revealed a robust barrier for the transmission of CWD to macaques which, again, is suggestive of a rather low risk for CWD transmission to humans [24].
As the end result of terminal differentiation, the robust barrier function of the skin protects against microorganism invasion and UV irradiation, inhibits water loss, regulates body temperature and is an important part of the host defense system [4].
Although the molecular mechanism is not clearly understood, it has been shown that the trophectoderm layer can serve as a robust barrier to lentivirus particles and protect the inner cell mass (ICM) from virus infection [15], and E-cadherins and tight junctions are suggested to contribute to this barrier function [16], [17].
Recently, we established an inverted cell culture insert model of PCPEC and HIBCPP that display robust barrier properties and enable investigation of pathogen and leukocyte transmigration in the physiologically- relevant basolateral-to-apical direction [ 7, 27].
These observations suggest that, in addition to sufficient (CH2) n groups to form a hydrophobic seal with periderm waxes, a robust barrier to water transpiration requires the rigidity and organized suprastructure typical of native periderms.
