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Two significant technological roadblocks to developing caspase-binding molecules are the poor solubility of a subset of the bacterially expressed proteins and the instability of the renatured proteins that results from rapid inactivating autolysis at high protein concentrations.
As the AACR-FDA-NCI Cabsenceiofarkers Collaborative states, absence of high-quality biospecimens is one of the most significant roadblocks to developing and validating biomarkers (Mandrekar and Sargent, 2009).
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The key issues of battery life and efficiency could become a roadblock to developing optimum functionality.
However, the major roadblock to developing a practical process has been the low yields, typically around 25%, well below those achievable for the production of other biofuels from the same feedstocks.
The main roadblock to developing new enteric fever diagnostics is overcoming the lack of reproducible immunological and microbiological signals found in the host during infection.
Working with older women and men globally to develop their capabilities, reduce their vulnerabilities and alleviate the challenges within their communities, HelpAge International has proven time and again that older persons are not roadblocks to development.
However, as the field has developed, the NIH has responded proactively to identify roadblocks and to develop solutions that will accelerate translation of basic discoveries to the clinical setting.
Computer programming, airline revenue accounting, insurance claims and call centres have all been outsourced to developing economies.RoadblocksBut before we get carried away with rosy visions of IT bringing huge prosperity to emerging economies, some big caveats need to be added.
These knowledge gaps have acted as roadblocks to the development of future-generation energy technology.
Water- and disease-related issues are major roadblocks to sustainable development.
Moscow then threw all manner of roadblocks in the way of the foreign companies trying to develop Sakhalin.
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