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O'Hare et al reported that hemodialysis (HD) patients who were male, diabetic, had been previously diagnosed with peripheral vascular disease (PVD), had high mean systolic blood pressure, or elevated phosphate levels had increased risks of future amputation [ 5].
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We also did not have precise information about smoking status and the calcium and phosphate levels, which might be associated with the risk of future amputation.
We also propose further reduced amputation rates if patients with an increased risk of future amputation (i.e. male sex, kidney disease) are identified and offered preventive treatment early.
These factors could be used to inform clinical management, particularly for diabetic patients who are at high risk of future amputation, so more aggressive early intervention may be warranted.
Excluding patients with past amputation might eliminate possible bias with regard to analyzing future amputation and provide a clearer interpretation of the effect of HPD on limb ischemia.
Diabetic patients with CLI have high risks of amputation and death.
Patients with Streptococcus pneumonia PF had a poorer outcome with a higher ICU mortality and a higher risk of limb amputation.
Wearing all those rings also reduces circulation in the fingers, and Brady puts himself at greater risk of finger amputation, probably.
Ulcer size >5 cm indicates a reduced chance of healing and increased risk of major amputation.
We did investigate risk of major amputation according to glycemic control.
Multivariate analysis of the technical success of percutaneous angioplasty does show a significant reduction for the risk of major amputation; 1-month ΔTcP o2 is also significantly associated with healing and with a reduced risk of major amputation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com