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Results suggest that householder capacity to engage in regular risk management is reduced by limited perceptions of risk susceptibility and severity, impeding cues to action and barrier concerns.
Others, such as medical ethicist Annelien Bredenoord, advocate and experiment with more hybrid policies for dealing with and reporting back different ranges of findings to those who are interested, including findings of only potential personal significance such as slight changes in genetic risk susceptibility or findings which might inform reproductive decisions (Bredenoord et al. 2011).
We have taken a candidate approach to identifying moderate risk susceptibility alleles for ovarian cancer.
A non-parametric SNP-based linkage analysis performed using the Merlin program [24] did not give significant or suggestive linkage signals (maximum LOD score of 1.62 for chr14: 27.526–29.525 Mb), further suggesting a complex mode of inheritance with possible multiple low risk susceptibility loci, rather than a risk attributable to a major gene(s).
The era of genome-wide association studies to look for low risk susceptibility alleles was not yet upon us.
At least 20 SLE risk susceptibility loci have been mapped using both candidate gene and genome-wide association strategies.
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Cyclin-dependent kinase inhibitor 2A (CDKN2A) is the major high-risk susceptibility gene for melanoma.
The mechanism by which the low-risk susceptibility alleles confer breast cancer risks was obscure [ 10].
These findings provide interesting new clues for further research on these low-risk susceptibility alleles.
Genotypes of five low-risk susceptibility alleles [ 10] were determined in a cohort of 40 human breast cancer cell lines.
We present the genotypes of five low-risk susceptibility alleles or SNPs of 40 human breast cancer cell lines.
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