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An understanding of the role of platelets in critical illness also highlights the potential for both the development of risk stratification schema and the use of novel, targeted therapies that might alter the natural history of sepsis, acute lung injury, and ARDS.
Standardized diagnostic criteria, validated risk stratification schema, and response criteria to therapeutic intervention exist for these related disorders which have recently been created to facilitate the evaluation of potential new therapeutic modalities (Dupriez et al. 1996; Barosi et al. 2005; Tefferi et al. 2006, 2007b; Passamonti et al. 2008; Cervantes et al. 2009).
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The need for a risk stratification scheme is pressing.
The traditional approach to assessing the probability of Candida as a cause of nosocomial BSI has relied upon assessing the number and type of risk factors (e.g., corticosteroid therapy, total parenteral nutrition); however, this strategy has proven to have little utility in critically ill patients and proposed schema for risk stratification have yet to be well validated.
A comparison of the identical analyses for the five (Figure 2D) versus four (Figure 2G) risk groups revealed that inclusion of GRG status within the stratification schema provided more a refined risk-profile than a stratification schema that excluded GRG status (compare Figure 2, E versus H and F versus I).
Risk stratification.
Knowledge of clinical associations will improve risk stratification.
This model, termed 'developmentally dependent predictor of relapse' (DDPR), significantly improves currently established risk stratification methods.
Risk stratification after myocardial infarction (MI) remains expensive and disappointing.
Watson, E. K. et al. Personalised cancer follow-up: risk stratification, needs assessment or both?
Subsequent hrHPV genotyping might contribute to better risk stratification.
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