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Risk reducing surgeries have led to cancer specific survival benefit as well as a reduction in all causes of mortality [ 177] but remain unclear if patients electing for risk reducing salpingo-oophorectomy should have concurrent opportunistic hysterectomy.
98 Two studies by Beattie et al 98 in 2009 and Scheuer et al 99 in 2002 investigated the adoption of prophylactic procedures, time from genetic testing to operative intervention, and predictors for undergoing risk reducing surgeries amongst BRCA carriers.
At our institution, where the internal clinical lab repeated all positive (and true negative) genotyping results before risk reducing surgeries were recommended, both analytic and post-analytic errors by external academic and commercial laboratories were noted in the years following the initial description of the BRCA genes.
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Research in larger populations having risk reducing surgery is warranted.
Women were censored at time of risk reducing surgery.
Overall, most female carriers (55%) opted for risk reducing surgery following their genetic test.
Fifty-five per cent of female carriers opted for risk reducing surgery; 43% oophorectomy; and 34% mastectomy.
Several studies report risk reducing surgery rates amongst patients receiving a VUS result.
Baseline cancer worry was not a significant predictor of risk reducing surgery by 3 years (P=0.4; KW) and risk reducing surgery did not reduce cancer worry (P=0.8; KW) in carriers by 3-year follow-up.
Individuals at increased cancer risk are usually offered regular screening for early detection and/or risk reducing surgery.
Increasing numbers of women are opting for risk reducing surgery particularly early RRO, which will substantially reduce the risk of both breast and ovarian cancer [ 24].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com