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However, rs13447623 and the common 3′ UTR SNP rs2155209 (MAF = 0.38) [ 7] were associated with late bladder toxicity (per-allele odds ratio [OR] 2.12, 95% CI 1.30 3.45, Ptrend = 0.003; and per-allele OR 0.57, 95% CI 0.35 0.92, Ptrend = 0.02, respectively); only rs13447623 contributed independently to bladder toxicity risk on conditional analysis (P = 0.03).
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In all compartmental models, of which differential equations models are one type, it is assumed that health and mortality risk are conditional on disease state.
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