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Due to the high risk of regression to the mean in this case, however, these results are probably biased.
We have previously underscored the risk of regression to the mean with such protocols, meaning that in well-performing ICUs the introduction of so-called evidence-based protocols will compromise care and impede progress and innovation [3].
The 12-month risk of regression was 55.2% (R. Insinga, unpulished data).
There is also the risk of regression to the mean given the low values of many courses at baseline.
In that analysis, the 12 month risk of regression of severe dysplasia to normal/HPV was ~11%.
No studies were found documenting the 12 month risk of regression of anogenital warts in the absence of treatment.
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The 2002 Angels are the prime example for teams that ignored the risks of regression.
The first two studies, by Kataja and De Aloysio, have been described previously and reported 12 month risks of regression of CIN 2 to HPV/normal of ~2% and 40% respectively [ 49, 65].
Nearly all HPV natural history studies report a risk of progression or regression of disease, rather than a rate.
Epidemiologic evidence to support age-dependency in the risk of progression and regression of HPV disease was found to be weak, and an alternative hypothesis concerning the time-dependence of transition rates is explored.
Since univariate analyses (not shown in tables) revealed the possibility of sex and age differences in the association between chronic pain and the risk of hospitalisation, regression analyses were also done with stratification on sex and age, controlling for all other variables.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com