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In sample I, the request to participate in a side study on social network implied an increased risk of refusal to participate at first follow-up if subjects refused the request (RR 8.34).
However, if subjects participated in the network study, their risk of refusal was decreased (RR 0.42).
Factors associated with increased risk of refusal and abandonment: greater distance to the centre (P < 0.001), younger age (P = 0.017) and earlier year of diagnosis (P < 0.001).
In sample II, requests to participate in one to four side study cycles increased the risk of refusal to participate at second follow-up if subjects participated in fewer cycles than requested (RR 9.21).
If subjects participated in all side study cycles that they were approached for, even if the number of cycles was five or more, this had an opposite effect: it decreased the risk of refusal (RR 0.18).
Enrollment during morning hours was also associated with an increased risk of refusal.
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The etiologic fraction (EF) was calculated according to the formula, RR being the relative risk of cubicle refusal, f being the rate of cubicle refusal among cows from herds practicing rearing in slatted floor pens [ 1].
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We could have used the Kish method, but it requires, before the selection, describing exactly the whole family, more time and more risk of generating refusals than does the next-birthday method.
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CEO of Professional Science Editing for Scientists @ prosciediting.com