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The impact of body mass index (BMI) on the risk of reclassification and deferred treatment in active surveillance (AS) programs has not been thoroughly assessed.
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Severe acute injuries, or chronic illness and injuries among military personnel with high BMI potentially increase the risk of training restrictions, reclassification and/or discharge from military service [ 45].
For example, the c-statistic is largely unaffected by the mean risk in the population whereas measures of reclassification may be affected by where the reclassification cutpoint is set in relation to the distribution of risk in the population [ 14].
The method of reclassification groups predicted risk estimates into clinically relevant categories and cross-classifies these categories for 2 different, but nested prediction models.
The use of faecal calprotectin in addition to EPAGE criteria improved the risk reclassification of patients by endoscopic findings.
If we alter the existing clinical criteria, the reclassification risk refers to the proportion of patients reclassified into new risk-of-death categories [ 26].
Modified Cox proportional hazards regression was used to model the risk of death across eGFR and reclassification categories.
We compared the predictive powers of AAs and conventional risk factors for risk of diabetes using the net reclassification index (NRI), the integrated improvement index (IDI) and Harrell's C statistic [ 23, 24].
49 Although this genotype added minimally to the ability of the Framingham risk score to discriminate future events, improving the area under the receiver operating characteristics curve by only 3%, it did significantly improve reclassification of risk of coronary heart disease, albeit modestly.
From the analysis of the risk reclassification again no significant difference between both groups was found.
Instead, we have quantified the degree of correct risk reclassification by calculating the NRI index [ 52].
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