Sentence examples similar to risk of prolongation from inspiring English sources

It is unclear if the use of rilpivirine and a QTc prolonging medication would result in an accentuated risk of QTc prolongation.

Regulatory authorities state that these drugs should not be administered to patients already using another drug with QT-prolonging properties or to patients who have an increased risk of QT prolongation [ 5, 6].

The new warning also is separated from other warnings and precautions on the label, she said, "to provide some additional guidance to physicians" treating patients "who are already at risk of QT prolongation".

A survey was developed to elucidate physicians' perception of risk of QT prolongation (Appendix).

Consideration should be given to the metabolism of amiodarone by CYP3A4 and also its risk of QTc prolongation, though the incidence of associated TdP is less than 1%[16]].

65 However, evaluating the risk of QTc prolongation in cancer patients is not straightforward.

Prior to clinical development of romidepsin, in vitro electrophysiological assays were performed to assess the potential risk of QT prolongation.

The former may sample a restricted group of patients and may not be reflective of the medical comorbidities or concomitant treatments that may increase risk of QT prolongation.

CYP3A4 and CYP2C9 variants predisposed to an increased risk of QT prolongation or torsade de pointes induced by antimicrobial agents, with the exception of quinolones [ 37].

Given a low risk of QTc prolongation, a strict ECG screen at baseline and during treatment was incorporated in the protocol.

Despite a more favorable acute side-effect profile compared to older agents, it is associated with risk of QTC prolongation and a potential for arrhythmias [ 10].