Exact(8)
The risk of mutations caused by these agents inhabiting in the wetlands will pose threat on their existence.
The key advantages of this approach include facile amplification, restriction enzyme-free library generation, and a significantly reduced risk of mutations outside the targeted region and wild-type contamination as compared with current methods.
We usually choose people from the same sub population, but avoid genetic relatives because of the risk of mutations in offspring.
An important observation from these studies is that the risk of mutations and treatment failure with raltegravir seems to be increased in patients with a higher baseline HIV-1 RNA levels and lower CD4 cell counts.
It also increases with the number of cell divisions that generated the leukaemia: the larger the number of cell divisions the higher the risk of mutations, and therefore the higher the probability of resistance.
A loss of H3K4me2 impairs the body's ability to control DNA damage in cancer because it increases the risk of mutations and, consequently, cancer development (Lennartsson and Ekwall 2009).
Similar(52)
The avian flu situation in Indonesia is grave, and the risk of mutation into a human pandemic form will worsen if more is not done, the United Nations Food and Agriculture Organization warned last week.
The genomic DNA was assayed for integrated plasmid using a sensitive PCR method, and the risk of mutation due to integration of pcS/2SS plasmid following intramuscular injection in mice was negligible.
However, even conservative repair of DSBs by homologous recombination is associated with a highly elevated risk of mutation.
Both mechanisms (employment of HR as a repair pathway and blockage/removal of non-repairable HSCs) likely contribute to lower the risk of mutation accumulation in ageing HSCs.
A bigger genome should induce higher probability of mistakes in DNA replication during cell division, leading to higher risk of mutation and concomitantly to cancer.
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