We recruited an external review expert, asking her to support the researchers in verifying the analysis of the panellists' responses in each round and the final report, to lower the risk of subjective interpretation.
In addition, information about confluency (CCL values) is obtained simultaneously, reducing the risk of false interpretation of TEER values [ 53].
This conclusion, however, takes study-level variation as indicative of individual-level variation and thus carries the risk of an interpretation error ("ecological fallacy") [ 75].
To enhance validity and limit the risk of predetermined interpretation, the second author, not having taken part in the project earlier, independently read and coded the data.
The grounded theory methodology used to code survey responses adds the risk of data interpretation errors, such as evaluators imposing their own meanings or not considering discrepant data.
To avoid false associations we took all sentences used by Pathway Studio (Ariadne Genomics) to determine gene associations and searched for co-occurrence of specific words: modifiers of sentence meaning, indicating increased risk of false interpretation.
These results define the lung as the main lactate-producing organ in septic hyperlactatemic patients with ARDS, which in the absence of a pathological supply dependency of oxygen consumption outlines the risk of wrong interpretation of serum lactate levels as a surrogate marker of tissue hypoxia in these patients.
Possible disadvantages given by respondents for working with informal interpreters were that it posed confidentiality issues (43%), there was a risk of mis-interpretation by the informal interpreter (9%) as well as a recognised lack of medical terminology (11%).
Our work was mainly to provide standardized signs, a major advantage of lung ultrasound, because the risk of wrong interpretations is highly decreased.
The investigators (IE, IH) had a preunderstanding that could increase the risk of over-interpretation.
