Sentence examples for risk of integration from inspiring English sources

We sequenced and mapped the GLOBE integration sites in the human cells to assess the risk of integration in potentially dangerous loci and showed that GLOBE integrates at low copy number into the human genome without preferential targeting of proto-oncogenes, tumor-supressor or cell cycle related genes.

IRLs provide a way to assess the risk of integration besides TRL, which only assesses the technologies themselves [4, 5, 9].

The merits include no risk of integration into the host genome, cell cycle-independent transfection efficiency, no need for immune inducible vectors, and adjustable and rapid expression.

Notable advantages include no risk of integration into the genomic DNA, adjustable gene expression and easier modulation of the immune system.

Recent advances of mRNA-based gene transfer provide notable advantages including no risk of integration into the genomic DNA, adjustable gene expression and easier modulation of the immune system.

Indeed, low but definite risk of integration and insertional mutagenesis, risk of germline transmission and risks related to immune responses to either vector or transgene product are aggravated with the vector dose and its multi-organ diffusion (54).

In the last decade, AAV-mediated gene delivery has emerged as an effective and safe tool for both pre- clinical and clinical studies of genetic disorders, since the vectors are not pathogenic in humans and mice, remain episomal (thus reducing the risks of integration into the genome), and persist for long time.

The field needs to be maintained and strengthened and transitioned beyond an emphasis on quantification of risk to integration of genetics in the search for genes affecting cancer risk associated with radiation.

The insertion of exogenous DNA sequences using HDR templates demonstrated by Schumann et al. further opens the possibility of precisely integrating transgenic elements, thereby reducing the risk of gene integration in oncogenic sites caused by viruses.

For example, some of the currently available reprogramming protocols harbor the risk of transgene integration and mutagenesis, which are not clinical friendly[29].

The lower risk of air integration and the higher amount of acetic acid leads to the recommendation for TS of around 30%, but as the silage with lower moisture showed lower pH probably due to reduced dilution, this should be investigated under practical conditions for future optimization.