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APPLES requires finding organisms of a specified relational distance for comparison, which can burden the user, and MEME has the statistical risk of discarding actual existing motifs.
This approach is effective to significantly reduce the number of noisy seeds, but also has the risk of discarding correct ones.
While this might reduce the risk of widely applying a therapy that only worked in a subpopulation, it would increase the risk of discarding a therapy that was of high value, but only in a subpopulation.
However, one of the drawbacks of such an early screening strategy would be the risk of discarding athletically able young horses (on the results of an early temperament test), where potential behavioral problems during the middle to latter stages of the horse's career could be resolved through behavioral modification techniques.
Similar(55)
With multivariate analysis, we found a significantly higher risk of discarded PROs for female patients with HOOS Pain, HOOS PS, and HOOS Qol compared to patients with OHS.
For the generic PROs, the EQ-5D Index and EQ-5D VAS had a higher risk of discarded questionnaires than SF-12 PCS/ MCS; adjusted OR for EQ-5D Index was 1.4 (CI: 1.0 2.1) and for EQ-VAS it was 2.6 (IC: 1.9 3.6).
If quite a high value is chosen for "usually," say 0.9 to only exclude pairs which almost always occur together, then there will be only a low risk of wrongly discarding any genes which might be of interest.
If survival was quintupled in patients with a target present in 15% of patients, the therapy would be at risk of being discarded in our 668 patient simulated study since the study would not achieve statistical significance (HR=0.81, p=0.06), but would be accepted as effective if the target were present in just 11 more patients (16.7%) (HR=0.79, p=0.04).
And instead of discarding, we'll reuse.
This residual vitality implies that manipulation of discarded vaccines may involve risk for infection.
Images of discarded tires also run that risk.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com