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The risk of differentiation into hypertrophic cartilage does not seem to be increased for OA chondrocytes.
Accordingly, the risk of differentiation into the hypertrophic cartilage lineage thus does not seem to be increased for the OA chondrocytes.
Thus, OA chondrocytes show a chondrogenic differentiation potential comparable with ND chondrocytes and the risk of differentiation into the hypertrophic cartilage lineage thus does not seem to be increased.
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The risk of unwanted differentiation and inadequate aging is another possibility strictly related to the treatment efficacy itself.
If the ASC population leans towards the self-renewal pathway, it risks the loss of differentiation capacity and could malignantly transform into a highly proliferative nondifferentiating cellular population.
Nth admission classes turn out to be meaningless in terms of risk differentiation.
Novel non-integrating iPSC reprogramming strategies may decrease risk, while increasing the efficiency of differentiation or the purity of the final cell product could minimize teratoma risk (Tang et al, 2011).
The parameters for these wellness programs, crafted by each insurer, could be used by the insurers as a means to educate and motivate their members, lessen risk and as a point of differentiation in their sales/marketing efforts to attract new members, just as all major automotive insurers have done through "safe driver" programs.
This may reflect photoreceptor biology in the sense that toward the end of differentiation, the risk for a photoreceptor to die increases dramatically, to then remain constant once full differentiation is reached.
Multivariate analyses revealed that WBC count before administration of anthracycline-based chemotherapy was an independent risk factor for the occurrence of differentiation syndrome (DS) (P = 0.006, OR = 1.022, 95% confidence interval (CI) = 1.006 1.038).
Young-age patients and those with higher risk of disease recurrence (tumor differentiation grade etc).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com