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Plant-based oral vaccines run the risk of activating regulatory T cells (Tregs) and suppressing the antigen-specific immune response via oral tolerance.
Since dexamethasone intravitreal implants have been shown to be very effective in managing intraocular inflammation both in non-infectious [7] and infectious uveitis [8], and a local approach has the advantage of reducing the risk of activating tubercular systemic disease, we considered this treatment a suitable option for our patient.
As tolerance has not been established to such peripherally modified self-peptides, citrullination might increase the risk of activating pathogenic T cells.
Moreover, vectors carrying β-globin promoters and LCR elements restrict transgene expression to the differentiated progeny within a single lineage, thereby reducing the risk of activating oncogenes in haematopoietic stem and progenitor cells.
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There are two ways of activating NMDARs.
Evidence supports that physical activity can significantly reduce the risk of depression, though activating this population remains challenging.
Taken together, these studies support the hypothesis that PCOS increases the risk of diabetes by activating chronic inflammation [ 5].
However, these therapies risk activating methylated oncogenes.
These findings do not support the hypothesis that ESAs could increase the risk of disease progression by activating EpoR on tumour cells.
While estrogen has normal biological roles, such as reproduction, brain development and additional protective effects of sexual steroid hormones, prolonged exposure, combined with high levels of hormone increases the risk of BC by constitutively activating the transcription of genes predominantly implicated in metabolism and cell cycle regulation.
39 40 Thus, we speculate that GSD may contribute to the risk of ISSNHL because it activates the immune system and possibly the subsequent inflammatory pathways.
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