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Objectives: Evaluate the risk of accumulation of midazolam and conjugated 1-hydroxy-midazolam in high-risk ICU patients treated by continuous veno-venous haemofiltration.
The knowledge of natural ventilation in underground constructions can help to optimize the design of their ventilation systems, reduce their energy consumption, and avoid the risk of accumulation of gases or toxics agents.
If low-molecular-weight heparin is chosen, its dosage should be adapted (elimination principally renal) to prevent a risk of accumulation and the occurrence of hemorrhagic complications.
Fondaparinux is a safety treatment of HIT, even though is not recommended in acute renal failure (ARF) because of it renal elimination and significant risk of accumulation.
Biodegradable polymers reduce the risk of accumulation of plastic materials in the environment and the cost of waste management of production and usage process [23].
Importantly, sufentanil displays a higher therapeutic index (26.000 vs 71 with morphine) and lacks active metabolites (Babazade & Turan, 2016), thus allowing a quicker achievement of optimal analgesia without the risk of accumulation and major side effects.
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Cholestasis leads to increased risks of accumulation of potentially toxic bile acids, chronic Kupffer cell activation, and deterioration of nutritional statuses [ 23].
This poses the risk of their accumulation in the ecosystem, which may call on health hazard.
As the membrane tubing is immersed in a flask filled with the substrate solution, diazomethane is instantly consumed, which minimizes the risk of diazomethane accumulation.
In liver failure, citrate metabolism is impaired with the risk of citrate accumulation.
The entrance of untreated wastewater or disposal leachate to water resources such as surface water, groundwater or irrigation water increases the risk of contaminant accumulation.
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