Exact(36)
At a molecular level, some of these risk mechanisms appear to overlap across a spectrum of neurodevelopmental disorders.
From these data and exome sequencing, more than 100 risk loci have been confirmed to converge on molecular risk mechanisms, including synaptic plasticity, immune function, and chromatin remodeling.
In addition, interventions do not directly target known risk mechanisms.
However, it may simply be that non-psychotic outcomes share only some of the risk mechanisms, or different risk mechanisms, to psychosis.
One major motivation for undertaking genetic studies is to identify underlying biological risk mechanisms.
This is especially important because data available to distinguish between different risk mechanisms is sparse.
Similar(24)
Predictive accuracy in women with previous cervical surgery (a potentially different risk mechanism) is not known.
Our findings establish disturbed connectivity as a neurogenetic risk mechanism for psychosis supported by genome-wide association, show that rs1344706 or variation in linkage disequilibrium is functional in human brain, and validate the intermediate phenotype strategy in psychiatry.
In this study we use an endophenotype-based approach to test predictions of biological effects on Aβ42 levels for variants in CLU and CR1 and to attempt to generate biological hypotheses of risk mechanism for BIN1, CLU, CR1 and PICALM.
This theorized risk mechanism carries clear implications for intervention.
This suggests a broader molecular risk mechanism for psychosis.
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